Design of machines and equipment used in pharmaceutical industries need special attention which are not normally considered in other industries. For example, finish quality of a machined surface of reactor is very important in pharmaceutical industry to avoid material accumulation and contamination. Similarly, packaging of drugs and medicines is one of the most important operations in pharmaceutical industry, which need special care during their design and fabrication. Some machineries and equipment are exclusively used in pharmaceutical industry, e.g., capsule filling machine which may be of semi-automatic as well as automatic type. Safety and reliability are also a major concern, in design of machines and equipment used in pharmaceutical industry. First of all, all the machines and equipment used in the pharmaceutical industry are needed to be validated in accordance with current good manufacturing practices (cGMPs). The resulting data are subject to examination by field investigators during routine GMP inspections.